Cyclodextrin-based Schiff base pro-fragrances: Synthesis and release studies

• Attila Palágyi,
• Jindřich Jindřich,
• Juraj Dian and
• Sophie Fourmentin

Beilstein J. Org. Chem. 2022, 18, 1346–1354, doi:10.3762/bjoc.18.140

• as the amount of released volatile increased with the RH%. In this experiment, we also observed a sustained release of the volatile compound from the imino-β-CD. Conclusion Here a new family of pro-fragrances using CD as substrate was prepared for the first time. A general, simple, and high-yielding

• the system. Sustained release of the aldehyde was demonstrated both in aqueous solutions and from a solid state upon humidity exposure. Experimental Instruments, general methods, and chemicals 1H NMR, 13C NMR, 2D NMR (H,H-COSY, HSQC, and HMBC) were measured on Bruker AVANCE III 600 MHz (600.17 MHz for

Host–guest interaction and properties of cucurbit[8]uril with chloramphenicol

• Lin Zhang,
• Jun Zheng,
• Guangyan Luo,
• Xiaoyue Li,
• Yunqian Zhang,
• Zhu Tao and
• Qianjun Zhang

Beilstein J. Org. Chem. 2021, 17, 2832–2839, doi:10.3762/bjoc.17.194

• sustained-release ability of drug molecules [31][33][34]. However, previous studies rarely reported the interaction between Q[8] and antibiotics, and did not explore the effect of Q[8] on antibacterial activity of antibiotics. Herein, Q[8] was selected as the host and the host–guest interaction between Q[8

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

• Luke O. Jones,
• Leah Williams,
• Tasmin Boam,
• Martin Kalmet,
• Chidubem Oguike and
• Fiona L. Hatton

Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171

• pore size range was between 50–300 μm, and small concentrations of laponite found in the gel wall helped with sustained release of a number of proteins with diverse properties [37]. Injectable nanocomposite cryogels have also appeared in research as a method to combat cancer. Bauleth-Ramos et al. used

• implanted. While optimum formulations were identified with the PAMAM dendrimer present, the release of BSP was relatively high within a 24-hour period, indicating that further development is needed to achieve sustained release with this system. After reviewing the recent diverse work currently being

• sustained release formulation. Potential fields of study here could include the increase in injectable cryogels that guide drugs (due to the pinpoint injection method and chemical sensitivity [82]) and nanoparticles to targeted sites maximising the efficiency of healing in modern day medicine. 5.3. Cryogels

Constrained thermoresponsive polymers – new insights into fundamentals and applications

• Patricia Flemming,
• Alexander S. Münch,
• Andreas Fery and
• Petra Uhlmann

Beilstein J. Org. Chem. 2021, 17, 2123–2163, doi:10.3762/bjoc.17.138

• , the developed GA-polyHMPA initially exhibits UCST responsiveness, but can subsequently be slowly biodegraded to a fully water-soluble polymer (polyHMPA) via hydrolysis. Initial in vivo studies of a sustained release of either a hydrophilic model protein or a hydrophobic dye entrapped within the

Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection

• Chelsea L. Rintelmann,
• Tara Grinnage-Pulley,
• Kathleen Ross,
• Daniel E. K. Kabotso,
• Angela Toepp,
• Anne Cowell,
• Christine Petersen,
• Balaji Narasimhan and
• Nicola Pohl

Beilstein J. Org. Chem. 2019, 15, 623–632, doi:10.3762/bjoc.15.58

• studies evaluating altered particle degradation rate(s) and encapsulation of trimannose within the particle could also be performed to provide sustained release of the trimannose. Conclusion Herein we described our newly designed pathogen-associated bioerodible microparticle 2 for investigation into the

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

• Qiang Wei,
• Theresa L. M. Pohl,
• Anja Seckinger,
• Joachim P. Spatz and
• Elisabetta A. Cavalcanti-Adam

Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87

• and BMP-2s are integrated in matrix metalloproteinase (MMP)-degradable PEG-maleimide hydrogels. The peptide ligands successfully host stem cells in vivo, and the sustained release of low doses of BMP-2 direct endogenous stem cell differentiation and promote bone healing [87]. Furthermore, the signal

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

• Hale Ünal,
• Naile Öztürk and
• Erem Bilensoy

Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22

• uptake. Therefore the particle size should be in an optimum range which enables particles to diffuse and permeate through the biological membranes, but also should provide the maximum ability for encapsulation of drugs and sustained release. The influence of CD concentration, concentration of oil phase

• attractive in terms of reduced dosing frequency and preventing fluctuation in blood concentration. By means of nanocapsules, sustained release of the drug with prolonged systemic exposure can be achieved with minimum side effects by accumulation of the dosed drug in the tumour tissues at a desired rate by

• release of encapsulated drug was found within a period of 72 hours. Results indicate that both of the formulations exhibited a sustained release profile. This observation can be explained by the slow release of CPT from the nanocapsules. These results suggest favourable release behaviour for an effective

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

• Kayoko Hayashida,
• Taishi Higashi,
• Daichi Kono,
• Keiichi Motoyama,
• Koki Wada and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2014, 10, 2756–2764, doi:10.3762/bjoc.10.292

• liposome and evaluate it as a sustained release drug carrier. PEGylated liposome encapsulating doxorubicin was disrupted by the addition of α-CD. Meanwhile, γ-CD included two PEG chains and/or one bending PEG chain of PEGylated liposome and formed PPRX without the disruption of the membrane integrity of

• the PEGylated liposome. Moreover, the release of doxorubicin and/or PEGylated liposome encapsulating doxorubicin from the PPRX was prolonged in accordance with the matrix type release mechanism. These findings suggest the potential of γ-CD PPRX as sustained release carriers for PEGylated liposome

• products. Keywords: cyclodextrins; doxorubicin; PEGylated liposome; polypseudorotaxane; sustained release; Introduction Cyclodextrins (CDs) are cyclic oligosaccharides comprising six (α-CD), seven (β-CD), and eight (γ-CD) glucopyranose units. They are characterized by a hydrophobic central cavity and a

Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• the reported ABC systems cannot provide enough volume for high drug loading, and as a result, a large amount of a nanocarrier is required to administer a desired drug dose [31]. Furthermore, sustained release, which is needed to control the release of drugs to the desired site within a given period of

• release was obtained by taking advantage of the stimuli-responsive property of the PDMAEMA segments. Furthermore, the cumulative amounts of LND released from DLMP1, DLMP2 and DLMP3 were only 18.4, 15.5, and 9.2%, respectively, within the release time of 48 h, indicating the clear sustained release

• behaviour. A similar sustained release phenomenon was also observed in other high drug loading, multifunctional nanocarriers [31]. More importantly, it can be seen from Figure 6a that the sustained release ability of DLMP3 was enhanced as compared with DLMP1 and DLMP2 after the release of 6 h. For example

Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• and the affinity of biocide for CDs allow to obtained unique sustained release systems with switchable properties [78]. In the context of prevention and management of wound infections, Garcia-Fernandez et al. highlighted the role of HP-β-CDs as main components of hydrogels and gauzes for the efficient

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• -fluorouracil and tamoxifen, as is shown in Table 1. Considering their versatility, nanosponges can act as multifunctional carriers, i.e., to enhance solubility, protect fragile molecules, and achieve sustained release. In many cases they act with two or more functions simultaneously. In this review we

• in vitro release and permeation of oxygen. The nanosponge/hydrogel system produces a slower sustained release of the gas. Therefore, nanosponges could be suitable carriers for topical oxygen delivery in the presence and in the absence of US and could act as an oxygen reservoir. Conclusion Nanosponges